Cefuroxime has bactericidal activity against a wide range of common pathogens, including beta-lactamase producing strains. The bactericidal action of cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases. Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. Clavulanic acid binds to and inactivates them thus preventing the destruction of cefuroxime that is a substrate for this enzyme. It has poor intrinsic antimicrobial activity, but it is an irreversible binder of ß-lactamases produced by a wide range of gram positive and gram negative 

Pharyngitis/Tonsillitis, Acute Bacterial Otitis Media, Haemophilus influenzae (including beta-lactamase–producing strains), Moraxella catarrhalis (including beta-lactamase–producing strains), Acute Bacterial Maxillary Sinusitis. Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis, Uncomplicated Skin and Skin-Structure Infections, Uncomplicated Urinary Tract Infections, Uncomplicated Gonorrhea, Early Lyme disease (erythema migrans).

  Adolescents and Adults (13 years and older)
 Pharyngitis/tonsillitis 250 mg b.i.d. 
 Acute bacterial maxillary sinusitis 250 mg b.i.d. 
 Acute bacterial exacerbations of chronic bronchitis 250 or 500 mg b.i.d. 
 Secondary bacterial infections of acute bronchitis 250 or 500 mg b.i.d. 
 Uncomplicated skin and skin-structure infections 250 or 500 mg b.i.d.
 Uncomplicated urinary tract infections 250 mg b.i.d. 
 Uncomplicated gonorrhea 1,000 mg once single dose
 Early Lyme disease 500 mg b.i.d. 

 Patients with known hypersensitivity to cephalosporin antibiotics.

Anaphylactic reaction to penicillin. Pseudomembranous colitis Over growth of non susceptible or ganisms.
Paediatrics: Not safe in children below 3 months.
Pregnancy: Use with caution.
Lactation: Use with caution.

Skin rashes, Eosinophilia and transient increase of hepatic enzymes.

 Synergy with aminoglycosides.

 10X6