Ceftriaxone is a broad-spectrum semi-synthetic third-generation cephalosporin with a potent bactericidal activity against a wide range of gram-positive and gram-negative bacteria. Sulbactam is ß lactamase inhibitor.
 

Ceftriaxone & Sulbactam is used for treatment
•        Respiratory tract infection, Urinary tract infection
•        Skin and soft tissue infection, Bone and joint infection.
•        Bacterial Meningitis, Surgical Prophylaxis

Common adverse drug reactions (ADRs) for the ß-lactam antibiotics include
• Loose stools or Diarrhea
• Nausea, Vomiting, Skin Reaction
• Headache and Dizziness
• Elevations of SGOT/SGPT

The bactericidal activity of ceftriaxone results from inhibition of bacterial cell wall synthesis. Ceftriaxone exerts in vitro activity against a wide range of Gram-negative and Gram-positive micro-organisms. Ceftriaxone is highly stable to most beta-lactamases, both the penicillinases and cephalosporinases, of Gram-positive and Gram-negative bacteria.

Sulbactam irreversibly blocks the destruction of beta-lactam ring of Ceftriaxone by these wide variety of ESBLs and chromosomally mediated beta-lactamases by attaching to these enzymes and acting as a suicide substrate that forms a stable intermediate, rendering the enzyme inactive.

CEFTRIAXONE is highly active against Gram+ve, Gram-ve aerobic, & anaerobic bacteria., Highly effective in treating infections due to multidrug –resistant Enterobacteriaceae., Highly effective as perioperative prophylaxis of surgery.

SULBACTUM shows synergistic activity with ceftriaxone against H. influenza, E coil, Bacteroides species, Staphylococcus species, Klebsiella

Okacef-SB is contraindicated in patients with known allergy to penicillins and cephalosporins. Warnings Serious or occasionally fatal anaphylactic reactions have been reported in patients receiving beta-lactam antibiotics. These reactions are more likely to occur in individuals with a history of hypersensitivity reactions to multiple allergens.

Before taking this medicine, tell the doctor about any medical problems and allergies that the patient has now or has had in the past.

From the above discussion, it can be concluded that this Ceftriaxone with Sulbactum improve the quality of life and help to cure Respiratory tract infection, Urinary tract infection, Skin and soft tissue infection, Bone and joint infection, Bacterial Septicaemia, Bacterial Meningitis, Surgical Prophylaxis.