Domperidone is a peripheral dopamine D2-receptor antagonist, which regulates the motility of gastric and small intestinal smooth muscle. It increases the duration of antral and duodenal contractions and also LES resting pressure, thus stimulating gastric emptying and is also effective in relief of symptoms of reflux esophagitis. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone. 
Omeprazole inhibits the secretion of gastric acid by irreversibly blocking the enzyme system of H+/K+ ATPase of the gastric parietal cell. It is activated at an acidic pH to a sulphenamide derivative that binds irreversibly to H+/K+ ATPase, an enzyme system found at the secretory surface of parietal cells. It thereby inhibits the final transport of hydrogen ions (via exchange with K ions) into the gastric lumen.

Gas
Acidic stomach
Abdominal pain 
 Belching and heavy bloating  Treatment for symptoms associated with idiopathic or diabetic gastroparesis
Heartburn  
Gastroesophageal reflux disease
Bitter fluid into stomach
Food pipe healing
Treatment for intractable nausea and vomiting

Co-administration with potent CYP3A4 inhibitors
Concomitant use with medicines that prolong the QT interval
Congestive heart failure
Gastric malignancy
Hypersensitivity
Hypersensitivity to domperidone

Avoid driving or operating machinery
Concurrent use with QT prolongating agents
Discontinue use if experiencing signs or symptoms associated with cardiac arrhythmia
Do not chew or crush the tablets
Do not take double dose for making up forgotten dose
Do not use if you are allergic to omeprazole

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