Diclofenac: It is a non steroidal anti inflammatory, analgestic and antipyretic, drug. Diclofenac inhibits prostaglandin synthesis by interfering with the action by prostaglandin synthetase which explains its action. It is ideally suited for patients on sodium free diet, hypertensive patients, to treat painful inflammatory conditions of patients on diuretic therapy.

Paracetamol: (Acetaminophen) Paracetamol is a valuable central analgestic but weak peripheral anti inflammatory agent and exhibits good and prompt antipyretic action. It does not stimulate respiration, or after acid base balance and causes less gastric irritation and have no effect on cellular metabolism or clotting factors. It is not uricosuric. 

Serratiopeptidase:The mechanism of action of Serratiopeptidase appears to be hydrolysis of histamine, bradykinin and serotonin. Serratiopeptidase also has a proteolytic and fibrinolytic effect. This is achieved by dissolving the complement (specific proteins responsible for inflammation) and increasing the plasmin activity by inhibiting the plasmin inactivators. 

• Post operative and post traumatic inflammation muscular and skeletal pain and other co-existing conditions like spondylitis, Rheumatoid arthritis and Osteoarthritis.
•  Pain, Fever.
•  Resolution of inflammation due to bone and soft tissue injury. 
•  Reducing inflammation associated with episiotomy and perineal laceration. It reduces breast engorgement in puerperium. Helps to resolve postpartum  haematomas and pregnancy related thrombophlebitis. It is also indicated as adjuvant after hysterectomy.         
•  As adjuvant in chronic obstructive pulmonary disease, bronchitis, pulmonary tuberculosis, bronchial asthma, septic abortion, pelvic inflammatory disease and salpingitis .       

3 times daily.

Peptic ulcer, known hypersensitivity to the active substance, acetyl salicylic acid or other prostaglandin synthetase inhibiting drugs.

• Nausea, rashes, leukopenia is rare.
• Skin rash, diarrhea, loss of appetite, gastrointestinal disturbance and nosebleed. 

Enhances oral anticoagulant activity. Absorption increased by metoclopramide. Absorption reduced b pethidine, propanthline. Alcohol (chronic use) potentiates hepatotoxicity by paracetamol.

Caution should be exercised in patients with history of liver or kidney disease, during pregnancy and breastfeeding.

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